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According to the Lilly statement, this discovery is concerning because nothing is known about the short- or long-term effects of this molecule in humans, or whether there are any potential impacts on the drugs efficacy, toxicity, or immune reactions

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On the other hand, APOA5 knockouts had an increase (+ 400%) in TG levels whereas APOA5 transgenic mice displayed significantly reduced ( 70%) in this lipid parameter [48]