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Vukojevic et al., 2020) or reduced L-NAME-induced retinal ischemia in rats (Zlatar et al., 2021)

Rather than directly activating GABA-A receptors, the peptide appears to maintain homeostasis of the entire GABA receptor complex, preventing the desensitization and compensatory changes that produce tolerance and dependence

One modulates the chemical environment

Safety & Considerations Active cancer or cancer history

The retinoid comparison makes GHK-Cu discontinuation appear favorable since copper peptide cessation typically produces gradual benefit decline without rebound worsening or dramatic rapid reversal

A published review of how this copper peptide supports skin repair and collagen outlines its roles in wound healing, inflammation control, and collagen stimulation across several tissue types