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Mol Med Rep 12(2):23012306 Yang J, Hua Z, Zheng Z, Ma X, Zhu L, Li Y (2023) Acteoside inhibits high glucose-induced oxidative stress injury in RPE cells and the outer retina through the Keap1/Nrf2/ARE pathway

Lancet 374 , 3947 (2009)

Anderson HR, Butland BK, & Strachan DP (1994) Trends in prevalence and severity of childhood asthma

Avari H, Savory E, Rogers KA (2016) An in vitro hemodynamic flow system to study the effects of quantified shear stresses on endothelial cells

Ionomycin significantly increased PS exposure in all conditions when compared to the DMSO control: Ringer (2.4% to 24%, p =0.0004), Ringer+Albumax (0.72% to 22%, p =0.0005), iRPMI (0.63% to 23%, p =0.0003) and iRPMI+Albumax (0.43% to 15%, p =0.0329)

In this context, myeloid populations, including neutrophils, macrophages, monocytes, and dendritic cells, emerge as key regulators of immune escape and therapeutic persistence by reinforcing immune-suppressive niches, limiting effective antigen presentation, and promoting tissue remodeling that supports resistant cellular states (shown in Figure 5 )