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Based on results reported here, PC cells with VRK2 high expression can tolerate GSH inhibition because of its sufficient antioxidant capability which reflected by low basal level of ROS and high basal level of GSH

Bloomer RJ, Fisher-Wellman KH, Tucker PS

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This process is mediated by the PINK1/Parkin pathway: Upon collapse of the m, PINK1 stabilizes on the outer membrane and recruits the E3 ubiquitin ligase Parkin, which tags damaged mitochondria for autophagic degradation (101)

J Transl Med 19:397

Okay E, Karadenizli A, Muezzinoglu B, Zeybek U, Arzu Ergen H, Isbir T: N-acetylcysteine attenuates bacterial translocation after partial hepatectomy in rats