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doi: 10.1128/spectrum.03713-23 75 SchwendickeF.WalshT.LamontT.Al-YaseenW.BjrndalL.ClarksonJ

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Phosphorylation of MCU enhances mitochondrial Ca 2+ uptake, precipitating mitochondrial Ca 2+ overload, opening of the mitochondrial permeability transition pore (mPTP), loss of m, release of pro-apoptotic factors and progressive mitochondrial dysfunction (59)

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They engage overlapping but not identical pathways, serve somewhat different experimental purposes, and have very different research depth in the published literature

As a notable finding, treatment with NAC-S2 improved the survival rate to 90% and significantly ameliorated inflammatory responses (105)