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For example, catalpol attenuates depression-like behaviour in pathological hyperglycaemic states, and its antidepressant mechanism is attributed to the upregulation of PI3K/AKT/Nrf2/HO-1 signalling pathway by reversing the abnormal phosphorylation of PI3K and Akt, as well as the abnormal levels of Nrf2 protein, HO-1 and superoxide dismutase, glutathione peroxidase, glutathione transferase, and reducing glutathione (Zhao et al., 2012)

The number of Cys residues in the CSD motif was mapped onto the phylograms manually

Read our Research The science of Glutathione Glutathione (GSH) is one of the brains most important antioxidants

Cell Death Dis 15 , 534 (2024)

This phenomenon might suggest why quercetin had a similar dynamic behavior as that of FAD when bound to the protein but didnt show quality behavior as compared to other two phytochemicals

Surprisingly, glutaredoxin was present in a more reduced form in the trr1 mutant