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First, advanced delivery platforms, including microneedles, nanoparticles, and hydrogel-based systems, should be designed to enhance cutaneous retention, epithelial penetration, and pharmacokinetic stability

However, issues included the use of toxic cyanide-containing substances, the high cost of resolving agents and catalysts, the challenge of utilizing the other enantiomer from the resolution, numerous reaction steps, low yield, high cost, and high product price

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only TPM3 (WT) TG3, and TPM3 (E151G) TG1 and TG2 had significantly lower body weight compared to AB(WT) (Fig

& Helm, R

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