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10.1016/j.carbpol.2022.120265 213 Meyer-DruL.DavidG.AuvergneR

HPLC testing: High-performance liquid chromatography confirms peptide identity and purity

However, many reported GSH-responsive systems demonstrate incomplete drug release under physiological intracellular GSH levels (110 mM), suggesting an overestimation of redox sensitivity in vitro

doi: 10.1038/s41392-024-01840-1 143 GersztenREGarcia-ZepedaEALimYCYoshidaMDingHAGimbroneMAJret al

Abnormal NLRP3 inflammasome activation and excessive IL-1 secretion is the major reason of CAPS, and has been demonstrated in three clinical subtypes: neonatal-onset multisystem inflammatory disease (NOMID), Muckle-Wells syndrome (MWS), and familial cold autoinflammatory syndrome (FCAS)

HO-1 has the potential to stimulate the angiogenesis by elevating the expression of several pro-angiogenic factors including VEGF, translational growth factor-1 (TGF-1), and stromal-derived factor-1 (SDF-1) [130, 131]