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Free radicals are compounds that contain one or more unpaired electrons that are highly reactive and able to oxidize lipids, proteins, carbohydrates, and DNA (34)

ALS presents as different phenotypes, with the spinal and bulbar phenotypes being the most common

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A more heterogeneous group of TIGRFAM annotations are over-represented after menarche, belonging to a variety of functional categories and including functions related to DNA replication, salvage of nucleosides and nucleotides, degradation of RNA, and electron transport