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African green monkeys treated with RVX-208 for 63 days elevated plasma Apo AI and HDL cholesterol levels up to 60% and 97%, resulting in increased cholesterol efflux via ABCA1, ABCG1 and SR-BI pathway 131

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[DOI] [PubMed] [Google Scholar] Mandel, S

on the other hand, glutamine-derived isotopologues such as citrate m + 4, fumarate m + 4 and m + 2 (second round of oxidation), malate m + 4 and m + 2 (second round of oxidation), as well as aspartate m + 4 (coming from oxaloacetate directly or indirectly produced from the TCA as a result of further citrate oxidation in the cytoplasm) and m + 5 (originating from transamination reaction using labeled amine from glutamate and labeled carbons from oxaloacetate) are indicative of oxidative glutaminolysis (Fig

Die Analyse erfolgt blicherweise mittels chromatographischer Verfahren und dient vor allem der Abklrung von Strungen im Aminosurenstoffwechsel