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The addition of glucagon receptor activation introduces direct thermogenic and lipolytic effects that neither GLP-1 nor GIP agonism provides alone, creating a mechanism that, in some ways, bridges the gap between the direct fat-targeting approach of AOD 9604 and the systemic metabolic reprogramming of tirzepatide

Then, the Hh transportation from the posterior to the anterior was blocked by expressing ttv-RNAi in the dpp-Gal4 domain, obvious apoptosis was consistently observed in the central wing discs (Fig