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Dupixent in clinical trials Dupixents approvals for COPD were mainly based on data from two Sanofi-sponsored, similarly-designed Phase 3 clinical trials: BOREAS (NCT03930732) and NOTUS (NCT04456673)

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Signs of cobalamin deficiency in dogs A dog with cobalamin deficiency may have one or more of the following symptoms: Lethargy Loss of appetite Change in eating habits Dull coat Loss of muscle mass Weight loss Weakness Diarrhea Loss of interest in playing Failure to thrive Mental dullness Seizures Cobalamin deficiency in dogs primarily occurs when there is a problem with cobalamin absorption