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Description

In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas

L., Piuri, M

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CPT-11 resistant CRC cell lines demonstrated downregulation of topoisomerase I mRNA and increased cellular export of SN-38 ( 2.5 Tumor microenvironment 2.5.1 Tumor-associated fibroblasts Tumor-associated fibroblast (TAF)-derived CCL2 and downstream transcription factor Ets-1 are associated with TAF-induced fibroblast growth factor receptor 4 (FGFR4) upregulation in colorectal cancer cell lines