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The observed effect of DPI2 was comparable to that of erastin, indicating that DPI2 might trigger cellular ferroptosis via a mechanism analogous to that employed by erastin ( Sorafenib, a multikinase inhibitor, has gained widespread use in the treatment of clinically advanced hepatocellular carcinoma, offering patients prolonged survival

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11 , e1005153 (2015)

E.Herrera-MarschitzM.IsraelY

Since the liver typically suffers from increased cell turnover and damage as people age, apoptosis is significant