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Melatonin helps maintain oocyte integrity and functionality by scavenging ROS and enhancing endogenous antioxidant enzyme activity ( Recent studies have also shown that melatonin can improve the survival and developmental competence of oocytes derived from small antral follicles (89)

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Reactive oxygen species (ROS), a group of highly reactive molecules containing oxygen, including superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), singlet oxygen, and hydroxyl radicals (OH), can interact with lipids, proteins, and nucleic acids within cells, leading to oxidative stress [5]

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