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Although hypotheses such as the reactive species hypothesis involving oxygen and C-centred radicals or carbocations, and the heme (Fe) activation hypothesis (or heme model) are related, they are also different from each other

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After knocking out the ZEB1 gene related to lipid uptake, aggregation, and migration, the sensitivity to ferroptosis and susceptibility to ferroptosis inducers was significantly increased, leading to drug-resistant cancer cell death [78, 98]

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10.1111/ics.12612 108

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