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The histidine residue serves as the primary copper-binding site through its imidazole ring, creating a stable square-planar copper(II) complex with the amino terminal and adjacent peptide nitrogen atoms

The molecular systems involved include actin cytoskeletal remodeling and integrin signaling, with focal adhesion pathways facilitating attachment of fibroblasts to collagen

Conclusions The observed overlap in PRO measures across BSA groups shows that at the time of initiation of biologic therapy, patients with low BSA have similarly poor quality of life and high symptom burden compared with patients with higher BSA involvement

Histology and Histopathology

FDA Approves Cilta-Cel for Earlier Lines of R/R Multiple Myeloma | Targeted Oncology Immunotherapy, Biomarkers, and Cancer Pathways