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Monitoring and adjustment We check in during the cycle

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This cisplatin resistance is partly due to the hypoxic tumor microenvironment (TME), which results in elevated expression of HIF-1, which is involved in the induction of angiogenesis, changes in the glucose metabolism, cell proliferation, inhibition of apoptosis, invasion and metastasis, finally leading to an adaptation to the hypoxic TME [159]

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