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The ability of IL-12/IL-23 cytokines and IL-18 to induce NK-1R expression can be explained due to the ability of both of these cytokines to elicit cellular effects via NF-kB activation (Weinstock et al., 2003a), and the fact that the promoter region of the NK-1R gene contains a binding site for this transcription factor (Takahashi et al., 1992)

Methods: We selected single-nucleotide polymorphisms (SNPs) that are strongly associated with exposure as instrumental variable and conducted a bidirectional two-sample Mendelian randomization (MR) study to explore the causal association between serum total bilirubin and cholelithiasis

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& De Cosmo, S

10.7759/cureus.19401 Nazia Khan, Irma Hashmi, Liana Atallah, Hamid Shaaban, Gunwant Guron, Andre Fedida

To view a copy of this licence, visit About this article Cite this article Kaufmann, P., Bergmann, A