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This mechanism has also been confirmed in uveal melanoma (UVM) [50, 51]

Solution-phase complement activation and IgG complex formation assays Solution phase complement assays were performed by incubating anti-NIP IgG1 WT, REW, RGY, and PGLALA in NHS (Complement Technologies) at a concentration of 100 g/mL for 1 h at 37 C

46 It has been demonstrated that ROS are likely to participate as immunosuppressive agents in cancer microenvironment and facilitate tumor invasion, metastasis, and resistance