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During the initiation stage, ROS may produce DNA damage by introducing gene mutations and structural alterations of the DNA

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FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma

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Interventions that target the SENP3/CTH pathway or provide H 2 S donors, such as ATB346, may be effective for AAA treatment (78)

However, mutagenesis introduces random changes to the DNA that could result in the loss of advantageous traits