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(4) Except as provided in paragraph (g)(4)(ii) of this section, if an ACO or CMS terminates the ACOs participation agreement during the agreement period in which it received prepaid shared savings, the ACO must repay all outstanding prepaid shared savings it received in full upon request from CMS

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It is critical to recall that all of this data comes from preclinical models (rodent, porcine, in vitro) and limited case studies

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