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Consistent with the human genetic study, PGRN deficiency has been shown to exacerbate Gaucher disease-associated phenotypes of Gba1 D409V/D409V knockin mice [214]

[63] first reported the existence of G protein-coupled receptor (GPCR) GLP-1R in human hepatocytes in 2010, and provided evidence to prove the direct effects of GLP-1 protein on cells

It can abstract hydrogen atoms from the deoxyribose sugar backbone, leading to strand breaks, or add to the double bonds of DNA bases, resulting in base modifications such as 8-hydroxydeoxyguanosine (8-OHdG) [28]

The membrane was then washed and incubated with an HRP-conjugated secondary antibody for 1 h

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