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In conditioned place preference (CPP) studies conducted in rats, pregabalin (up to 30 mg/kg) did not cause rewarding effects and did not change place preference 15,16

Under oxidative stress these three systems work in concert to detoxify ROS and lipid peroxides, maintain protein structure and function via thiol repair, prevent activation of redox-sensitive inflammatory pathways, and preserve mitochondrial membrane integrity and prevent apoptosis

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To this end, many drugs have been repurposed, including tocilizumab, sarilumab, heparin, chloroquine, ivermectin, sarilumab, chromones ( Most of the effort has been so far devoted to the identification of medications capable to revert the worst and life-threatening complications of COVID-19, namely cytokine storm and hypercoagulation ( This crucial phase of the malady, in analogy with other viral infections and to a widely accepted pharmacological praxis, should be timely treated either with etiotropic drugs (which in COVID-19 case are still lacking) as well as with host-directed agents to manage/prevent the symptoms ( NSAIDs, Paracetamol, and COVID-19 In March 2020, ibuprofen and NSAIDs were discouraged because of the alert by Micallef et al

Consistent, daily dosing of Vitamin D3 is increasingly favored in clinical practice over massive, infrequent boluses, as it provides a more stable regulation of immunomodulatory hormones

High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy