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Additionally, miR-221 and miR-222 expression increases during early atherosclerosis, negatively correlating with eNOS signaling [89]

More recently, another study explored NAM supplementation in a golden retriever muscular dystrophy model, demonstrating increased NAD + levels in skeletal muscles and improved skeletal muscle function 266

166,167 Muscle-enriched miR-486 was induced by exercise and was necessary to mediate the beneficial effect of exercise in reducing I/R injury and myocardial apoptosis through targeting PTEN and FoxO1