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Preclinical and animal studies validate the clinical findings on AOD 9604 by demonstrating its clear impact on fat metabolism and 3-adrenergic receptor activity

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Preclinical Studies Early preclinical studies in rodent obesity models demonstrated that AOD9604 administration reduced body weight and fat mass without affecting food intake, indicating a direct metabolic effect rather than an appetite-suppressing mechanism

Subject terms: Biochemistry, Cell biology, Metabolic disorders Introduction Nicotinamide adenine dinucleotide (NAD + ) is an essential redox coenzyme that exists between the oxidized form NAD + and its reduced form (NADH) 1