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In mice, feeding of a vitamin E-deficient diet (2 mg RRR-T/kg diet) for 3 months reduced, whereas RRR-T supplementation up to 9 months (200 mg/kg diet) did not alter hepatic mRNA expression of Cyp3a11 (the murine homologue of the human CYP3A4) compared with control (20 mg/kg diet) ( Reference Kluth, Landes and Pfluger 56 )

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Their findings revealed a significant reduction in glucose production and expression of both G6pc and Pck1 in hepatocytes with NNMT overexpression and concurrent Sirt1 inhibition, compared to hepatocytes with NNMT overexpression alone

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The ischemia/reperfusion (I/R) injury that follows cerebral occlusion can initiate a cascade of events including redox imbalance, excitotoxicity, dysregulated inflammatory response, mitochondrial dysfunction, and apoptosis which ultimately lead to a neuronal loss [89]