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However, the IV route takes the drug directly into the bloodstream which results in 100% bioavailability instantaneously while in the case of an IM route, drug is injected into muscle tissues, which holds the drug for a while and slowly releases into the bloodstream through the network bed of capillaries running across or surrounding the muscle tissue

Although HIF-2 has biochemical characteristics similar to those of HIF-1, the metabolic role of HIF-2 in a low-oxygen environment is relatively unknown 68

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Akt activation plays a pivotal role in mitigating ischemia-reperfusion injury by suppressing apoptotic pathways, enhancing cell survival signals, and promoting Nrf2 nuclear translocation [23]