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We found that both glycine and succinyl-CoA, along with their precursors, serine (which generates glycine through serine-glycine one-carbon metabolism) and propionyl-CoA (which is transformed into succinyl-CoA through the reaction catalyzed by the PCCA-MMUT-MCEE complex, Figure 4e ), were significantly increased in Alas1 KO adipocytes ( Figure 4a and Extended Data Figure 7a )

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