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Previously regarded as a disease of the young and middle-aged, contemporary registries from the Western world have demonstrated an increase in the age of patients with PAH, many of whom are elderly with multiple comorbidities

Physiologically, it serves as an essential cofactor in the conversion of methylmalonyl-CoA to succinyl-CoAa substrate for the tricarboxylic acid cycleand plays fundamental roles in DNA and protein synthesis, methylation cycles, and folic acid metabolism (73)

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[5] [6] Como el glutatin, ascorbato y NADPH estn presentes en altas concentraciones en las clulas vegetales, el ciclo del glutatin-ascorbato juega un papel clave para la detoxificacin del H 2O 2

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Klimas and Gordon Broderick used the a Consortium Award from the Congressionally Directed Medical Research Programs (CDMRP) to develop an animal model and to use exercise, massive data gathering efforts and computational biology to attempt to understand the processes at work in GWI and identify potential treatment targets