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Renal denervation prevents immune cell activation and renal inflammation in angiotensin II-induced hypertension

This oxidative damage activates signaling pathways that promote inflammation and fibrosis, leading to glomerular hypertrophy, mesangial expansion, and tubulointerstitial fibrosis [183]

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The toxic metabolites retained as a result of altered kidney function contribute to the inflammatory state and drive fibrosis in kidneys, which is why patients with CKD must undergo dialysis

Moreover, the oral intake of bromelain reduced the expression of the cell surface markers CD44 but poorly increased the expression of CD11a and CD62L without changing the level of CD16

Thiols such as glutathione, alpha lipoic acid and N-acetyl-L-cysteine (NAC) are powerful sulfur-bearing antioxidants