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CB-1158 could block myeloid cell-mediated inhibition of T cell proliferation, increase the number of tumor-infiltrating CD8 + T cells and NK cells, and increase the expression of inflammatory factors and interferon-, thereby changing the immune microenvironment to promote inflammation and reduce tumor immune escape, inhibiting tumor cell proliferation

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(1) The key antioxidants are vitamins C, E, glutathione, anthocyanidins (in blue/red foods), lipoic acid and co-enzyme Q10

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doi: 10.1038/nm.4050 307 VeenGGiltayEJDeRijkRHvan VlietIMvan PeltJZitmanFG