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Your brain uses at least 20% of your oxygen supply to function which makes it highly susceptible to oxidative stress

doi: 10.1111/tid.12823 145 MaschanMBlagovSShelikhovaLShekhovtsovaZBalashovDStarichkovaJet al

Collagen VI regulates peripheral nerve regeneration by modulating macrophage recruitment and polarization

(2014) 9:e91805

In summary, the binding of TNF-, IGF, and various leukotrienes to cell surface receptors activates the MAPK signaling pathway, which in turn upregulates COX-2 downstream, thereby mediating the bystander effect

All data were analyzed using an Eppendorf Realplex 2 and the relative expression levels were calculated using the 2 CT method