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All authors critiqued the manuscript, and read and approved the final version

Key representative preclinical studies summarizing CeO 2 NP formulations, surface modifications, biological models, and their main therapeutic outcomes are summarized in Table 3, providing a clear overview of their effects on oxidative stress, inflammation, angiogenesis, and macrophage modulation

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However, the involvement of vagal afferent nerves in mediating the effects of ghrelin remains a contentious topic (69) (Figure 2)

This conclusion was corroborated by the result of the application of the Maas-Hoffman model to assess the plant response to iodine supply, as a lower slope and a higher critical concentration (the threshold) was computed for Red Rubin than for Tigullio ( Table 3 )