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Redox Signal 24 , 680712 (2015)

To date, no drug treatment has been approved against NAFLD, however, lifestyle alterations, physical exercise, and weight loss can regulate oxidative stress and the life cycle of mitochondria

Cell Death Differ 23(9):15021514

Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages

The cells were incubated in serum-free DMEM medium including 0.1% DCFH-DA at 37 C for 20 min and then washed with serum-free DMEM three times

Its dietary sources include heme ironfound in red meat, animal offal, and blood-based products, which exhibits higher bioavailabilityand non-heme iron (from plant sources such as spinach, legumes, and fortified grains)