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In addition, the infectious burden hypothesis suggests that chronic or repeated infection may contribute to development of atherosclerosis and cardiovascular disease via hardening and narrowing of arteries over time (118)

Measurements were made for three independent samples per spectrum

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Instead of macrophages being either M1- or M2-polarized, they are mostly somewhere in between, often expressing both types of markers simultaneously ( TAMs are mainly M2-like anti-inflammatory macrophages with the ability to reduce a potent anti-tumor immune response

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