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Importantly, serum BDNF reflects platelet release during clotting rather than direct brain levels, so its clinical utility as a biomarker remains debated

do not prove clinical benefit in humans

Zamanian MY, Khachatryan LG, Heidari M, Darabi R, Golmohammadi M, AlAouadi RFA, et al

Mass spectrometry: This testing method confirms molecular weight matches the expected peptide structure

Disorders of androgen receptor sensitivity or enzymatic defects in T synthesis may also manifest during this phase (normal/elevated testosterone levels associated with relatively elevated gonadotropins in androgen receptor defects, reduced T levels with variable gonadotropins in enzymatic defects of gonadal steroidogenesis)

DSD due to 5-reductase 2 deficiency - from diagnosis to long term outcome