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Chimeric class I PtGRXs containing the class III GRX-specific SCCMC motif instead of the YCGYC (PtGRXC1) or YCPYC (PtGRXC4) motifs, respectively, showed moderately to severely reduced oxidoreductase activity depending on the construct, allowing the conclusion that the peculiar active sites of class III GRXs are principally permissive for oxidoreductase activity

DNA binding of the glucocorticoid receptor is not essential for survival

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Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: a phase 1b/2 clinical trial and correlative analyses

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10.1016/j.biopsych.2006.06.004 Biol