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Frequency : DSIP is typically administered once per day, 30-60 minutes before bedtime, to maximize its sleep-enhancing effects

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Patients with normal immune function would be suited for standard treatment protocols, whereas those with impaired immune function, such as those on long-term immunosuppressive therapy or with immunodeficiency, might need tailored treatment adjustments to optimize efficacy and minimize side effects (183)

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Some users report subtly improved hydration or a slightly less dull texture at this point, though tone change is typically still minimal or not consciously noticeable