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2016;(68 Suppl 3):59

Estrogen receptor signaling mechanisms

Given dimenhydrinate and doxylamine share the same mechanism of action, it is recommended that no more than 200 mg dimenhydrinate be given to a patient concurrently taking doxylamine.[16] Multiple studies have been conducted that have failed to find any association between dimenhydrinate and congenital anomalies.[32-34] Ondansetron (Zofran) Ondansetron is a commonly used anti-emetic that works by antagonizing serotonin at the 5-HT3 receptor peripherally at the vagus nerve terminal as well as centrally at the chemoreceptor trigger zone

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Downstream effects include concentration-dependent suppression of lipogenesis (50-70% reduction), decreased adipocyte size, and increased basal energy expenditure without appetite suppression

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