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Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

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The substrate protein is then delivered by Hsc70 to the lysosome membrane, where Hsc70 assists in substrate unfolding [8]

Thalidomide analogs (also known as immunomodulator imide drugs, IMiDs)anti-cancer agents that function through this mechanismresurface the E3 substrate receptor, CRBN, to induce the recruitment, ubiquitination, and degradation of neo -substrate targets, including therapeutically important transcription factors 1019