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doi: 10.2174/1389201021666200109104701 31 IchinoseR.FukudaY.Yamasaki-YashikiS.KatakuraY

Cancer 3 , 253266 (2003)

Dicer is essential for mouse development

MECHANISM OF ACTION OF RADIOPROTECTORS Radioprotectors exert their effects through several mechanisms including scavenging free radicals by exhibiting antioxidant properties, enhancing DNA repair by triggering DNA damage repair pathways, donating a hydrogen atom to the radical formed during the interaction of IR with cellular molecules predominantly water, hypoxia induction in tissue, modulating redox sensitive genes, regulating the activity of growth factors and cytokines and by inhibiting apoptosis and delaying cellular division, which provides additional time for cells to repair DNA damage or undergo cell death (Mishra et al., 2018