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It has also been linked with shifts in inflammatory markers in preclinical work

Given this breadth of information, in addition to the alveolar macrophage being first line of defense in the alveolar space and the dominant cell type that Mtb infects, we will spend the remaining portion of this section reviewing the specific effects of chronic alcohol misuse on the pulmonary innate immunity and how these alcohol-mediated alterations may intersect with Mtb pathogenicity