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Considering all these data together, it is reasonable to assume the existence of an RBC-Hb self-assembly system and a spontaneous system of drug release by RBCs after oral or intravenous administration of this drug, which provided a new understanding of the discrepancy between the high tissue concentration and extremely low plasma concentration of berberine

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Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, Yue Z, Bandopadhyay R, Glicksman MA, Moore DJ , Collins JJ, Wolozin B

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Firstly, the roles of GSH in cancer cells are introduced to demonstrate the importance of GSH exhaustion in anticancer therapy