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In 2017, DiMarchi and Tschop created a GLP1/dexamethasone conjugate which managed to improve body weight in DIO mice, in a superior way to GLP1 or dexamethasone alone

MPGES1 have a key role in inflammatory diseases and is high upregulated in tissues during inflammation and overexpressed in tumors 23

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Qiagen, Germany

Therefore, although the existing data collectively suggest promising protective roles for these compounds, further well-designed clinical trials are required to confirm their efficacy, determine optimal dosing strategies, and clarify their long-term impact on cardiovascular and metabolic health

10.1073/pnas.0400219101