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Drug repositioning: A brief overview

In particular, the transporter LAT1 is critical for the uptake of branched-chain amino acids (BCAAs) like leucine, which play a significant role in insulin secretion from pancreatic beta cells

Given that age and sex ratio were unevenly distributed between the ASD and HC groups and the HC subjects were from different sources (local community, kindergarten/primary school and clinical center) in some included studies (eTable 1), we performed the stratified analyses based on the three factors

Existing studies indicate that quetiapine can cause mitochondrial dysfunction, while therapeutic doses of aripiprazole show significant antioxidant protective effects under acute oxidative stress conditions in vitro (20)

Thus, it would be difficult to attribute the effect of fructose on obviating the Pasteur effect or enhancing tumor growth via alterations in lipid metabolism

Jouany, J.P., et al