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17 Screening should be considered in patients with risk factors, and diagnostic testing should be considered in those with suspected clinical manifestations

However, comprehensive human safety data for the combination remains limited

This is because a small amount (about 1%) is absorbed passively via diffusion

It cannot prove the medication is free of bacterial endotoxins

Patients with a clinically diagnosed B12 deficiency such as pernicious anaemia should be under GP care for ongoing management

Even simple activities like eating, speaking, brushing teeth, or feeling a light breeze can trigger intense episodes, making daily life unpredictable and stressful