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J Biol Chem 282:2958429593

Discontinuations for somnolence were also significantly higher than with placebo

NAC used as an add-on drug attenuated the development of morphine tolerance and dependence in mice and associated biochemical alterations, such as reduced GSH level and GSH peroxidase activity [45, 46]

ROS function in redox signaling and oxidative stress

Downregulation of ATP5A1, the ATP Synthase F1 Subunit Alpha [123], and ATP5G3, the ATP synthase F0 complex subunit C3 [124], was observed in the postmortem study of ASD patients in all examined regions [122], which could inhibit the activity of complex V [79] and promote the ETC breakdown due to opening of the mPTP [125, 126]