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A low baseline GSH level was the most common factor among patients with COVID-19 and risk factors identified to be associated with a high mortality rate including age, hypertension, ischemic heart disease, diabetes, and chronic respiratory disease [49]

This m elevation hints toward either a homeostatic compensation for some impairment in the AS mitochondrial respiratory chain or it can result from this impairment, ending up with the accumulation of unutilized hydrogen ions

Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway

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Using tissue-specific and single-cell RNAseq analyses, we delineate how the early-adult MetR impacts the transcriptome and tissue homoeostasis

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