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On the basis of impaired cushioning function, especially of large arteries, arterial stiffness causes (i) ISH, (ii) reduced coronary perfusion and increased afterload with resulting left ventricular diastolic dysfunction, and (iii) microvascular alterations with resulting end-organ damage (e.g., HFpEF, vascular dementia, and chronic kidney disease)

As with all other known types of arthritis, Gout has particular joints it tends to attack, and the foot is its most common location

The patient continues dosing without therapeutic effect

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